Recent research suggests that the protein Reelin may play a crucial protective role in the aging brain, particularly in relation to Alzheimer’s disease. Decreased production of Reelin in Alzheimer’s patients may contribute to neurodegeneration and dementia. Studies on individuals with a rare gene variant of Reelin have shown that they are protected from the cognitive effects of Alzheimer’s pathology. Efforts are now underway to develop drugs that can enhance Reelin levels or function to prevent cognitive decline.
In a groundbreaking study, a man with a rare gene variant of Reelin managed to stave off Alzheimer’s until his 70s, despite showing signs of the disease in his brain. Further investigations revealed that the unique Reelin variant he carried enhanced the protein’s ability to reduce tau tangles, a common characteristic of Alzheimer’s. Subsequent studies have confirmed that individuals with higher levels of Reelin-producing neurons tend to maintain cognitive function as they age. These findings highlight the importance of Reelin in protecting the brain from Alzheimer’s disease.
For a detailed analysis of the research on Reelin and Alzheimer’s, check out the article on NPR.
