Reviewing Cellular Senescence as a Driver of Ovarian Aging – Fight Aging!

Ovarian aging is a complex process that involves the accumulation of senescent cells, which contribute to a decline in fertility and menopause. Research in this area is crucial for understanding how cellular senescence impacts ovarian function and exploring potential interventions to slow down or reverse the aging process. Limited data suggests that senolytic drugs may prevent ovarian reserve loss but may not be able to fully restore lost function once senescence is established. Further research is needed to identify biomarkers of ovarian senescence and develop targeted therapies to eliminate senescent cells without harming other organs. The path to validating senotherapies in female reproductive aging is still open, with the potential for senomorphic compounds to reduce SASP secretion and prevent inflammation in the ovary. This ongoing research highlights the importance of understanding cellular senescence as a driver of ovarian aging and its impact on female fertility.