Trametinib and rapamycin, when used in combination, have been shown to significantly increase life span in mice more than rapamycin alone. The study found that the dual treatment not only extended life span in both male and female mice, but also reduced the occurrence of liver and spleen tumors, lowered age-related inflammation, and improved overall health. This promising discovery highlights the potential benefits of combining different geroprotectors to enhance longevity and combat age-related diseases.