Caloric restriction (CR) is a proven method to slow aging and prevent age-related conditions by reducing calorie intake while maintaining essential nutrients. One debated area is its impact on bone mineral density and osteoporosis. Recent research delves into the effects of CR on bone health in aged mice, revealing both positive and negative aspects. Despite an increase in bone marrow adipose tissue, CR showed potential benefits in maintaining trabecular bone structure in aging mice. It suggests that the timing of CR is crucial for optimal bone health. Further studies are needed to fully understand the effects of CR on bone biology.
This study examined the local impact of caloric restriction on bone composition, microstructure, and endocrine profile in aged mice. Results showed that CR increased bone marrow adipose tissue accumulation and adipogenic gene expression. Trabecular bone loss was attenuated in aged mice on CR, indicating potential benefits for age-related bone dysfunction. However, cortical bone was reduced in both young and aged mice on CR. Overall, these findings shed light on the complexities of CR’s effects on bone health in aging individuals.
Link: https://doi.org/10.3389/fendo.2024.1394263
