PKM2 Aggregation as a Pathological Mechanism in Senescent Cells – Fight Aging!

As we age, senescent cells accumulate in our bodies, releasing signals that disrupt tissue function and structure. While efforts are mainly focused on destroying these cells, some are exploring ways to suppress their harmful signaling. A recent study revealed that PKM2 aggregation drives metabolic reprogramming during aging, leading to cellular senescence. By identifying compounds that dissolve PKM2 aggregates, researchers were able to alleviate senescence and extend the lifespan of mice. This research sheds light on potential strategies to combat the effects of senescent cells on aging and age-related diseases.