The blood-brain barrier is a vital layer of cells surrounding blood vessels in the central nervous system, regulating the passage of molecules and cells to and from the brain. With age, this barrier weakens, leading to leakage and potential inflammation in the brain. Recent research suggests that this dysfunction plays a key role in the development of neurodegenerative conditions and cognitive decline.
A study exploring the connection between blood-brain barrier dysfunction and cognitive decline in aging individuals and those with neurodegenerative diseases found that vascular risk factors contribute to white matter injury and cognitive impairment through increased BBB permeability. Targeting these risk factors could help prevent cognitive decline in the future.
