Chronic inflammation is a common feature of aging, leading to various age-related conditions. Recent research suggests that IL-11, an inflammatory cytokine, plays a crucial role in this process. Inhibiting IL-11 signaling has been shown to extend the lifespan of mice by as much as 25%. This discovery opens up new possibilities for interventions targeting IL-11 to improve late-life health and longevity. Anti-IL-11 therapy could offer a promising approach to combat age-related pathologies in humans, with potential benefits for healthspan and lifespan.