Interest remains high in the use of vitamin B3 derivatives to boost NAD levels in mitochondria for improved function. While compounds like niacin, nicotinamide riboside, and nicotinamide mononucleotide show promise, human clinical data is lacking. Exercise still outperforms these approaches in NAD level increases. Research in mice suggests restoring youthful NAD amounts contributes to health.
NAD is crucial for energy metabolism, DNA repair, and sirtuin activity. Aging leads to NAD decline, impacting health. Long-term nicotinamide mononucleotide (NMN) supplementation in mice shows benefits in activity, gene expression, and reduced frailty without increasing cancer risk. NMN treatment positively influences gut bacteria and metabolic health, even extending female lifespan. NAD boosters hold potential for age-related conditions.
Link: https://doi.org/10.1101/2024.06.21.599604
