In the realm of omics analysis of the aging retina, researchers point towards senolytic therapies as a potential solution to combat age-related macular degeneration. This debilitating condition is closely linked to the presence of senescent cells in the retina and surrounding tissues, which trigger inflammation and problematic cellular behavior over time. Specifically, senescent retinal pigment epithelium (RPE) has been associated with the onset of AMD, prompting the exploration of senolytic agents as a potential treatment. Intercellular communication between RPE cells and the choroid plays a crucial role in this process, with pathways like VEGF, BMP, and tenascin-mediated pathways showing increased activity in interactions between senescent cell populations. These findings highlight the potential of anti-aging therapies like senolytic compounds to mitigate the progress of AMD and emphasize the need for further research into the interplay of senescence and cell-to-cell communication.
Arguing for Senolytics to Prevent or Slow Development of Macular Degeneration – Fight Aging!
