Towards Small Molecule Drugs that can Induce Trained Immunity
Trained immunity is a fascinating phenomenon that could revolutionize the way we approach vaccinations and immune system health. Researchers are making strides in identifying small molecule drugs that have the potential to induce trained immunity, offering broad benefits in enhancing our defenses against pathogens. This could lead to a lasting suppression of chronic inflammation associated with aging, ultimately improving overall immune function. The discovery of these small molecule inducers opens up new possibilities for therapeutic advancements and treatment modalities.
Trained immunity involves epigenetic and metabolic changes that enhance our body’s response to pathogens, providing a generalized protection against diseases. While current research primarily focuses on complex biological compounds like β-glucan or the BCG vaccine, the identification of specific small molecules holds great promise for understanding and harnessing the power of trained immunity. By screening a library of drugs and drug-like compounds, researchers have pinpointed several compounds that induce a training response without initial immune activation, including unexpected candidates like glucocorticoids. This breakthrough expands our knowledge of innate immune memory and paves the way for novel therapeutic approaches in immune system modulation.
