Mitochondria play a crucial role in producing ATP to power cell activity and are integral to cellular processes. Loss of mitochondrial function accelerates aging, characterized by dysfunctional mitochondria in aged tissues. Mitochondria, descended from ancient bacteria, replicate and fuse to maintain quality. Mitophagy removes dysfunctional mitochondria, ensuring cellular health. The balance between fission and fusion regulates mitochondrial function, impacting longevity. Overexpressing fission or fusion genes extends lifespan in nematode worms by promoting stress resistance. This study sheds light on the importance of mitochondrial dynamics in enhancing resilience and longevity.
The dynamicity of mitochondrial networks is vital for meeting cellular energy needs. Mitochondrial fission aids degradation and distribution, while fusion maintains function by complementing components. Increasing fission or fusion capacity in nematode worms showed increased fragmentation but extended lifespan and stress resistance. This study underscores the significance of mitochondrial dynamics in promoting biological resilience and longevity.
