Researchers have identified the cGAS-STING pathway as a key driver of retinal degeneration, linking it to maladaptive innate immune signaling. This pathway is of particular interest due to its role in chronic inflammation seen in age-related degenerative diseases. Distinguishing between harmful and beneficial inflammatory signaling remains a challenge. Glaucoma, a progressive optic neurodegenerative disease, is characterized by various mechanisms leading to the loss of retinal ganglion cells (RGCs). Strategies targeting DNA damage, such as the cGAS-STING pathway, show promise in reducing RGC loss in glaucoma. A mouse model of glaucoma revealed that suppressing cGAS-STING signaling protected visual function, highlighting a potential therapeutic strategy for the disease.
Blocking cGAS-STING Inflammatory Signaling Protects the Retina from Glaucoma – Fight Aging!
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