Lower Dose Senolytics Fail to Prevent Cognitive Decline in Female Rats
Researchers conducted a study evaluating the effects of lower doses of senolytic drugs on cognitive decline in female rats. The dosing schedule involved 5 days on and 14 days off for 7 months. Despite the prolonged treatment, the results showed no significant impact on cognitive decline in the female rats. This research adds to the ongoing exploration of senolytic therapies and highlights the challenges in determining the appropriate dosage for optimal effectiveness. Further research is needed to advance the development of senolytic treatments.
The study also explored the sex differences in response to senolytic treatment, focusing on the cognitive function of aging female rats. The findings revealed that the senolytic treatment did not mitigate cognitive decline in the female rats, raising questions about the role of hormonal changes in aging mechanisms. While previous studies have shown benefits of senolytics in male rats, this study underscores the complexity of addressing cognitive decline in aging females. More research is required to unravel the intricacies of senolytic therapy in different biological contexts.
Link: https://doi.org/10.3389/fnagi.2024.1384554
