The aging process not only affects the body externally but also impacts internal organs, including the brain. Cardiovascular disease plays a significant role in accelerating brain aging, as reduced blood flow can lead to functional decline over time. Mitochondrial dysfunction is a common factor in both vascular and brain aging, highlighting the interconnected nature of aging processes at the cellular level. Addressing mechanisms like oxidative stress and inflammation through lifestyle interventions and pharmacological treatments may help reduce the risk of dementia associated with aging. By exploring the relationship between peripheral vascular aging, cerebral vascular dysfunction, and brain health, we can develop new strategies for assessing and mitigating dementia risk in older adults. Check out the link for more information: https://doi.org/10.18632/aging.205877.