Increased mTORC1 Nutrient Sensing Shortens Life Span in Mice
Recent research has shown that increased activity of mTORC1, a protein involved in nutrient sensing, can actually shorten the lifespan of mice. Normally, inhibiting mTORC1 can have anti-aging effects by promoting cellular maintenance and repair processes. However, stimulating mTORC1 in mice through specific mechanisms was found to lead to inflammatory damage, increased myeloid inflammation, and a significant reduction in lifespan. This study sheds light on the intricate relationship between nutrient signaling, inflammation, and longevity in mammals. Read more
