Replication Stress as an Underappreciated Contribution to Cellular Senescence and Aging – Fight Aging!

Replication stress, a disruption during cell division that can lead to DNA damage and cellular senescence, is a fundamental process in understanding the age-related burden of aging. While commonly associated with progeria conditions, its impact on normal aging remains unclear. Recent research suggests that replication stress may also affect DNA repair processes and drive epigenetic changes linked to aging. This connection highlights the importance of studying replication stress as a potential biomarker for aging and age-related diseases. The complex interplay between replication stress, DNA damage, and cellular senescence underscores the need for further investigation into its role in the aging process.