300-400 kDa Hyaluronic Acid is Processed by Gut Microbes to Reduce Inflammation
Researchers have discovered that certain species in the gut microbiome respond to specific forms of hyaluronic acid by increasing production of a metabolite that helps reduce inflammation in the body. This finding adds to our understanding of how the gut microbiome can impact health. In cases where detailed knowledge is lacking, shortcuts like fecal microbiota transplantation can help reset an aged gut microbiome.
A recent study focused on the effects of hyaluronic acid with different molecular weights. Through advanced technologies, researchers found that hyaluronic acid within the 300-400 kDa range can effectively reduce inflammatory responses in mice. This process involves specific gut bacteria and a key metabolite – myristic acid.
The study revealed that hyaluronic acid stimulates certain bacteria to produce myristic acid, which then inhibits the NF-κB signaling pathway, ultimately reducing cellular inflammation. This research not only identified the optimal molecular weight range of hyaluronic acid for reducing inflammation but also provided insights into the mechanisms behind these effects and potential biomarkers for dietary strategies.
