Cardiovascular disease is the leading cause of human mortality, yet the current strategy of lowering LDL-cholesterol has not been effective in reducing this burden. Surprisingly, there are limited efforts to explore new approaches beyond this standard method. Research into novel ways to address aging and age-related diseases is also lacking crucial support. Atherosclerosis, a key factor in CVD, is primarily caused by inflammation, but most treatments fail to address this root cause. Aging itself is a major risk factor for CVD, highlighting the importance of investigating overlooked factors such as the gut microbiome. It is crucial to consider these factors in order to better understand and address age-related cardiovascular disease.
Recent evidence suggests that oxidative stress, inflammation, and vascular dysfunction are key factors in the pathophysiology of CVD. Aging contributes to these processes, leading to a complex interplay of events known as “inflammaging”. Understanding these factors is essential in developing effective strategies to combat age-related cardiovascular disease.
