The study of centenarians has revealed interesting insights into the protective mechanisms of aging. Transcriptomic analyses have shown that centenarians have a unique gene expression pattern, particularly with high expression of metallothioneins in astrocytes. These metallothioneins play a crucial role in maintaining homeostasis and protecting against cognitive decline. This study sheds light on potential protective mechanisms in extreme longevity and offers new avenues for research in aging and longevity. Read more about this groundbreaking research at https://doi.org/10.1111/acel.14201.