Research has shown a connection between the diversity of the oral microbiome and cognitive function. The oral microbiome can be assessed using 16S rRNA sequencing, revealing a correlation between microbial species diversity and cognitive decline. Inflammation caused by harmful bacteria like Porphyromonas gingivalis, responsible for gum disease, may play a role. Other factors such as overall health maintenance and cognitive function loss could also contribute. While causation cannot be definitively determined from epidemiological data, ongoing studies are shedding light on the potential link between oral microbiome diversity and cognitive function in older adults.
The study “Why Does Oral Microbiome Diversity Correlate with Late Life Cognitive Function?” explores the relationship between the oral microbiome and cognitive function in older adults. Using data from the NHANES 2011-2012 survey, the study found a positive correlation between oral microbial diversity and cognitive performance. Participants with higher microbial diversity showed better cognitive function and were less likely to experience memory changes. This association could be linked to systemic inflammation, as oral dysbiosis has been related to elevated inflammatory markers associated with cognitive impairment and dementia. Periodontal disease, a known contributor to oral dysbiosis, has been linked to increased levels of inflammatory markers, which can be reduced through treatment. These findings highlight the importance of oral health in maintaining cognitive function in later life.
