Cellular Senescence Disrupts Adrenal Gland Circadian Rhythm in Aging Mice
Recent research has revealed that the build-up of senescent cells in the adrenal gland of aging mice disrupts its natural circadian rhythm. This disturbance can have implications for various age-related diseases. By targeting and removing these senescent cells, researchers were able to restore the adrenal gland’s function and proper rhythm. This further emphasizes the importance of eliminating senescent cells in combating degenerative aging effects. These cells secrete harmful substances that disrupt normal cellular and tissue functions, contributing significantly to the aging process in the body and brain.
The study also highlighted the impact of age on the secretion of glucocorticoids (GCs) by the adrenal gland, which play a crucial role in metabolic and immune regulation. In older mice, there was an abnormal secretion pattern of corticosterone (CORT), with the disappearance of diurnal variation. Senescent cells were found to accumulate in the adrenal gland as mice aged beyond 18 months, leading to dysregulation of CORT secretion. By utilizing senolytic treatments and neutralizing antibodies, researchers were able to reduce the accumulation of senescent cells and restore the circadian rhythm of CORT secretion in aging mice. These findings shed light on the impact of senescent cells on aging processes and suggest potential therapeutic targets for age-related diseases.
Link: https://doi.org/10.1111/acel.14206
