Senescent T cells play a crucial role in contributing to neurodegenerative conditions as the aging immune system deteriorates. As T cells reach their limit in replication, they become senescent, leading to chronic inflammation and tissue damage. Studies have shown a link between T cell senescence, inflammation, and neuronal damage, highlighting the importance of addressing this issue in neurodegenerative diseases. This review explores the classification, function, and potential therapeutic strategies targeting senescent CD4+ T cells in the context of neurodegenerative conditions.