In the latest open access paper, researchers delve into the impact of bone marrow aging on chronic inflammation in the aging brain, a key factor in the development of neurodegenerative diseases like Alzheimer’s. As the source of immune cells, bone marrow shifts towards producing more innate immune cells as we age, affecting the balance of immune cell populations. This imbalance can disrupt brain function and contribute to neuroinflammation.
The immune system in the brain differs from that in the body, but is influenced by it. Factors like the blood-brain barrier and aging processes can affect immune cell transfer into the brain, exacerbating neuroinflammation. Understanding how bone marrow aging contributes to immunosenescence and neuroinflammation can provide insights into age-related neurological disorders and inform potential therapeutic strategies.
Dive deeper into the complex relationship between bone marrow aging, immunosenescence, and neuroinflammation with our mini-review, where we explore how changes in the bone marrow microenvironment impact immune cell homeostasis and function, ultimately affecting neurological health. By uncovering the cellular and molecular mechanisms at play, we aim to enhance our understanding of how aging impacts immune function and the progression of age-related neurological diseases.
