In Search of Natural Senolytics to Substitute for Dasatinib
Dasatinib and quercetin have shown promise in clearing senescent cells in aging mice, but the search for natural alternatives continues. Researchers aim to find plant extracts that mimic the effects of dasatinib, offering a less regulated option for combating age-related conditions. While trials in humans are ongoing, the exploration of compounds like piperlongumine and parthenolide as substitutes for dasatinib is in progress. The goal is to achieve similar rejuvenation effects with natural formulas.
Senescent cells play a significant role in age-related chronic diseases, making their elimination a crucial strategy for increasing healthspan. Natural compounds like piperlongumine, parthenolide, phloretin, and curcumin are being considered as substitutes for dasatinib based on gene expression similarities. These compounds target apoptosis-related pathways, offering potential as natural senolytics when combined with quercetin.
