A Decline in Stemness in Many Human Stem Cell Populations with Aging – Fight Aging!

A decline in stem cell function is a common feature of aging, similar to the accumulation of senescent cells. Stem cells are vital for tissue renewal and repair, but their activity decreases with age. Researchers have developed a stemness score based on transcriptomic data to assess the capacity for stemness in various human tissues. The study found that around 60% of tissues showed a negative correlation between age and stemness score, indicating a pan-tissue loss of stemness during human aging. This suggests that stem cell deterioration may contribute to the aging process. Further research is needed to understand and potentially reverse this decline in stemness.