Cellular senescence in macrophages is a key factor in degenerative aging. When macrophages become senescent, they exhibit chronic inflammation and compromised functions like phagocytosis and polarization. This can lead to various health issues and diseases in aged individuals. Specialized treatments targeting the unique characteristics of senescent macrophages are crucial for addressing different health conditions. For example, in cognitive decline, senescent macrophages have impaired phagocytosis, while in cancer, they promote tumor growth. Understanding the role of senescent macrophages in various organs and diseases is essential for developing effective interventions.
For example, in ovarian tissue, senescent macrophages contribute to ovarian aging by exhibiting a specific phenotype. Additionally, senescent macrophages secrete molecules that can exacerbate skeletal aging and contribute to age-related macular degeneration. Recognizing the impact of senescent macrophages on different tissues and diseases is crucial for advancing age-related research and developing targeted therapies.
Link: https://doi.org/10.1016/j.apsb.2024.01.008
