Delivery of TGF-β1 Following Heart Attack Reduces Reperfusion Injury
A heart attack is caused by atherosclerotic plaque rupture, leading to blockage of a vital blood vessel supplying oxygenated blood to the heart. The damage from a heart attack is exacerbated during reperfusion, as inflammatory responses and cell death contribute to scarring and loss of heart function. Researchers have shown that early application of anti-inflammatory signaling, specifically Transforming Growth Factor (TGF)-β1, can mitigate this damage and reduce the risk of heart failure post-heart attack. The study demonstrates the protective effects of TGF-β1 in reducing infarct size, inflammation, and scar formation in both human and mouse models of cardiac ischemia-reperfusion. The findings suggest that TGF-β1 delivery post-heart attack could be a promising intervention to prevent adverse ventricular remodeling and progression to heart failure in patients.
For more information and detailed study findings, check out the link: https://doi.org/10.1016/j.ajpath.2023.09.014
