Despite the success of early senolytic therapies in mice in clearing a significant portion of senescent cells and reversing aging, further progress requires a deeper understanding of cellular senescence. Variability in senescence across cell types presents challenges in identifying therapeutic targets and assessing senescence burden. The biology of senescent cells, including markers, dynamics, and adaptability, remains largely elusive. Uncovering the heterogeneity of senescent cells and the impact of subcellular features is crucial for developing effective senotherapies. Clinical trials targeting senescent cells are ongoing, but gaps in knowledge persist, necessitating initiatives like SenNet to advance research in this area. Integrating molecular and cellular techniques and data analysis tools can enhance our understanding of senescent cells and pave the way for more specific and efficient senotherapies.
A better understanding of essential features of Senescent Cells (SnCs) can lead to advancements in translational research and the development of new senotherapies. Questions about the role of senescent cell anti-apoptotic pathways (SCAPs) and the senescence-associated secretory phenotype (SASP) are key to mitigating the negative effects of SnCs and maximizing their beneficial impacts. Overcoming barriers such as lack of specific therapies and identifying the best timing for senescence intervention are critical for the successful application of senotherapies in a clinical setting. Ongoing clinical trials targeting SnCs highlight the need for further research to bridge the gap between molecular data and cellular observations. Initiatives like SenNet aim to create comprehensive atlases of SnCs to advance our understanding of these cells. Integrating various techniques and data sources is essential for unraveling the complexities of cellular senescence and developing more effective therapies.
Link: https://doi.org/10.1111/acel.14154
