Reversing Myeloid Bias by Selective Destruction of Hematopoietic Cells
The production of immune cells in the bone marrow shifts towards myeloid bias as we age, impacting immune function. Researchers explored the idea of selectively destroying myeloid-focused hematopoietic cells to reverse this bias, with promising results. By depleting myeloid-leaning cells in aging mice, a shift towards a more balanced immune system was observed, leading to better immune coverage and response to new infections. This findings may have implications for revitalizing aging human immune systems.
The study demonstrated that targeting myeloid-leaning hematopoietic stem cells in mice resulted in increased production of new, naïve lymphocytes involved in adaptive immunity. Furthermore, the treated animals showed reduced levels of inflammatory proteins and stronger immune responses to novel infections. These promising results suggest a potential strategy for improving immune function in aging individuals and enhancing responses to vaccinations.
