Proton pump inhibitors (PPIs) are a widely used class of drugs to treat heartburn, acid reflux, and other conditions. However, recent studies have linked PPIs to various health issues, including kidney damage, bone fractures, and dementia. Research from Washington University School of Medicine in St. Louis also found associations between long-term PPI use and an increased risk of death, as well as heart and kidney disease and stomach cancer. It is essential for individuals to be mindful of the potential risks associated with prolonged PPI use, and to consult with a healthcare provider before starting or continuing treatment with these medications.