A recent study has found that teens and young adults prescribed high doses of pharmaceutical amphetamines have a significantly higher risk of developing psychosis. Those taking ≥ 30 mg of dextroamphetamine, equivalent to 40 mg of Adderall, are at the greatest risk. Surprisingly, there was no link found between new-onset psychosis and past-month Ritalin intake.
Amphetamines are stimulants commonly used for various medical purposes, but misuse can lead to serious side effects like mania and psychosis. Concerns arise from the lack of upper dosage limits on medication labels, highlighting the importance of careful consideration when prescribing stimulants.
The study conducted by Dr. Lauren Moran revealed a substantial increase in psychosis risk with high amphetamine doses. Prescription guidelines should be adjusted to minimize these risks, with doses exceeding 30 mg of dextroamphetamine posing the greatest threat.
Although the study provided valuable insights, issues such as participants’ misuse of prescribed stimulants and observational study limitations were noted. Physicians are urged to be cautious when prescribing high doses of amphetamines, especially to individuals at risk for mental illness. Alternatives like Ritalin may be considered in these cases to mitigate potential risks.
