High-density lipoprotein (HDL) cholesterol, known as the “good cholesterol,” has long been praised for its cardiovascular benefits. However, recent research has uncovered a surprising link between very high levels of HDL and an increased risk of dementia in older adults. A study published in The Lancet Regional Health followed over 18,000 healthy adults aged 65 and older for six years, revealing a significant association between elevated HDL levels and the development of dementia.
The Study on HDL and Dementia Risk
The study found that individuals with HDL levels above 80 mg/dL were at a significantly higher risk of developing dementia, challenging the traditional belief that higher HDL levels are always protective for brain and heart health.
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Elevated Risk with High HDL Levels
Individuals aged 75 and older with very high HDL levels had a 42% higher likelihood of developing dementia, while even younger participants experienced a 27% increased risk.
Why High HDL Might Be Harmful
Researchers are exploring how high levels of HDL cholesterol may be linked to dementia, with some suggesting that excessive HDL levels could lead to vessel stiffening or brain inflammation, contributing to cognitive decline.
HDL’s Different Role in the Brain
High levels of HDL in the brain may increase stroke risk and trigger amyloid production, a hallmark of Alzheimer’s disease, suggesting that while HDL is beneficial in moderation, excessive levels could contribute to cognitive decline.
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Not Just About Cholesterol
Even after adjusting for traditional risk factors, the association between high HDL levels and dementia remained significant, highlighting the complex nature of HDL and its impact on brain health.
Should You Be Concerned About HDL Levels?
While HDL is generally beneficial, the research suggests that very high levels may raise concerns for aging individuals. Monitoring cholesterol levels within recommended ranges could help mitigate the risk of dementia.
Rethinking HDL’s Role in Health
This new research suggests a need to reconsider the perception of HDL as solely “good,” emphasizing the importance of balanced cholesterol levels for overall health and cognitive well-being in older adults.
Read More: Foods That Dementia Experts Want You to Eat More and Less Of
Sources
- “‘Good cholesterol’ and dementia: Researchers chart a correlation.” MSN. Linda Searing. February 2024.
- “Association of plasma high-density lipoprotein cholesterol level with risk of incident dementia: a cohort study of healthy older adults.” The Lancet. Sultana Monira Hussain, et al. February 2024.
- “How levels of ‘good’ cholesterol may increase dementia risk.” NBC News. Kaitlin Sullivan. October 4, 2023.
- “High levels of ‘good cholesterol’ may increase dementia risk.” Medical News Today. Kaitlin Vogel. December 7, 2023.
