Ozempic, originally intended for treating type 2 diabetes, has become a popular weight loss medication due to its appetite-suppressing effects. However, there is a potential downside of weight gain once the medication is stopped.
Understanding How Ozempic Works

Ozempic contains semaglutide, a hormone mimicker that reduces hunger and slows digestion. This leads to reduced calorie intake and weight loss. However, these effects are temporary, and stopping the medication can result in a return of natural hunger signals.
The Risk of Rebound Weight Gain

Studies show that few patients maintain their weight loss after stopping Ozempic, with many regaining lost weight and some even gaining additional pounds. This rebound weight gain is a significant concern for users.
Why Weight Gain Happens After

Dr. Ralph Abraham explains that the appetite-suppressing effects of Ozempic diminish once the medication is discontinued, leading to increased hunger and cravings. This can result in difficulty controlling food intake and subsequent weight gain.
The Importance of Behavior Change

To sustain weight loss post-Ozempic use, it is essential to adopt lasting lifestyle changes. Addressing underlying behaviors like overeating or lack of exercise is crucial for preventing weight regain. Ozempic should be part of a comprehensive weight management plan, not a sole solution.
Individual Responses to Stopping Ozempic

Individual responses to stopping Ozempic can vary based on dosage, duration of use, and metabolic factors. Some may need to continue the medication long-term, while others can successfully manage weight through careful planning.
The Future of Weight Loss with Ozempic

With the growing use of Ozempic for weight loss, understanding its risks and benefits is vital. Collaboration with healthcare providers to develop a holistic weight management plan involving diet, exercise, and behavior changes can help reduce the risk of weight gain post-Ozempic use.
Sources
- “Just 20% of Ozempic and Wegovy patients keep all the weight off after stopping – in more evidence pricey drugs are lifelong commitment.” Daily Mail. Emily Joshu. January 25, 2024.
- “Can you GAIN weight on Ozempic? Experts reveal how the drug can become useless…as Tracy Morgan says he gained 40 pounds while taking it.” Daily Mail. Maiya Focht. March 22, 2024.
- “Revealed: How Ozempic can make you pile on MORE weight after you stop taking it.” Daily Mail. Charlotte Dovey. August 6, 2024.