New research is uncovering the potential epigenetic changes that cannabis use can have on the human body, affecting gene expression and potentially influencing health outcomes. Epigenetics refers to changes in gene activity that do not alter the DNA sequence itself, with DNA methylation being one common form of epigenetic modification. Recent studies have found significant links between cannabis use and changes in DNA methylation, with implications for health outcomes and potential impacts on future generations. Researchers have identified DNA methylation markers associated with cannabis use that have implications for pathways involving cellular proliferation, hormone signaling, and mental health disorders. These findings suggest that cannabis use may influence genetic factors tied to these conditions. Additionally, cannabis use has been shown to affect the sperm epigenome, potentially impacting offspring health. Despite misconceptions about the safety of cannabis, its influence on the epigenome underscores the need for further research to understand the long-term effects of its use. As cannabis becomes more prevalent in society, it is important for both the public and policymakers to consider these potential health risks. Further research is needed to confirm these findings and explore how epigenetic changes may contribute to age-related health outcomes. This study marks an important step in uncovering the intricate connections between cannabis use, epigenetics, and overall health.