Ketamine and esketamine (Spravato) have emerged as revolutionary treatments for depression. Unfortunately, many individuals cannot afford these treatments due to their high costs. However, there is a new antidepressant on the market called dextromethorphan/bupropion that works similarly to ketamine and esketamine, offering a potentially more accessible option for those with treatment-resistant depression. Here’s a detailed comparison of dextromethorphan vs ketamine for depression treatment.
Ketamine Vs Esketamine? How Do They Work?
According to Medscape:
Ketamine is a dissociative anesthetic used off-label for major depressive disorder. It acts as an NMDA receptor agonist, leading to increased glutamate release and various downstream effects.
Esketamine (Spravato) is the active enantiomer of ketamine, approved by the FDA for treatment-resistant depression. It also functions as an NMDA receptor antagonist, elevating glutamate levels.
Ketamine Vs Esketamine — To Simplify
Ketamine comprises two mirror-image compounds: esketamine and arketamine. Esketamine is marketed as Spravato, approved for depression treatment, while ketamine is used off-label in IV form. Dextromethorphan is a new antidepressant approved in 2022, which combines dextromethorphan and bupropion.
Ketamine and Esketamine (Spravato) Are Expensive
Ketamine and esketamine are costly due to administration and observation requirements. Many individuals lack access to these treatments. Dextromethorphan/bupropion offers a more affordable alternative, available in pill form for home use.
Ketamine Vs Dextromethorphan/Bupropion (Auvelity)?
Auvelity combines dextromethorphan with bupropion, modulating glutamate levels similarly to ketamine. It provides a potentially cost-effective antidepressant solution for those with treatment-resistant depression.
Why Does the Alternative Depression Treatment Dextromethorphan Matter for People Wanting Ketamine?
Dextromethorphan offers a convenient and more affordable option compared to ketamine. It has shown fast-acting efficacy in treating depression, making it a promising alternative for individuals seeking effective treatment options.
Evidence for Dextromethorphan/Bupropion in Depression and Treatment-Resistant Depression Treatment
Studies suggest dextromethorphan/bupropion as an effective and well-tolerated option for treating depression, offering remission in many patients. It may be a viable alternative for those with treatment-resistant depression.
Dextromethorphan/Bupropion for Bipolar Depression
While evidence for bipolar depression treatment with dextromethorphan/bupropion is mixed, it remains a potential option for individuals facing treatment challenges. Further research is needed to explore its efficacy in bipolar depression.
What to Know About Dextromethorphan as an Antidepressant
Dextromethorphan, in combination with bupropion, presents a compelling option for individuals with depression, especially those resistant to traditional treatments. It offers a unique mechanism of action and affordability compared to other antidepressants.
Note: Always consult with your healthcare provider before starting any new medication. Understand the risks and benefits of treatment options to make informed decisions for your mental health.
Other Posts You Might Enjoy
